Insights into the subunit arrangement and diversity of paradoxin and taipoxin
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- 作者：Julian A. Harrisona ; b ; jah994@uowmail.edu.au" class="auth_mail" title="E-mail the corresponding author ; J. Andrew Aquilinaa ; b ; andrew.aquilina1@uowmail.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Elapids ; Venom ; Toxin ; Structure ; Mass spectrometry
- 刊名：Toxicon
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：45-50
- 全文大小：770 K
文摘
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Purification of paradoxin and taipoxin from whole snake venom.
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Analysed the native state of these trimers using mass spectrometry.
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Demonstrate that these toxins have similar architectures.
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Reveal that paradoxin and taipoxin contain previously uncharacterised subunits.
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Taipoxin exists as two distinct populations, due to multiple γ isoforms.