MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia
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- 作者：Elena Neumanna ; elena.neumann@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Timo Brandenburgera ; timo.brandenburger@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Sonia Santana-Varelab ; s.santana@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; René ; Deenenc ; rene.deenen@hhu.de" class="auth_mail" title="E-mail the corresponding author ; Karl Kö ; hrerc ; koehrer@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Inge Bauera ; inge.bauer@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Henning Hermannsd ; h.hermanns@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; John N. Woodb ; j.wood@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jing Zhaob ; jing02.zhao@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Robert Werdehausena ; robert.werdehausen@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：microRNA ; miR-1 ; Bdnf ; Gene deletion ; BDNF-Advillin-Cre-ERT2 ; Neuropathic pain ; Dorsal root ganglion
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：36-43
- 全文大小：1009 K
文摘
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Transgenic deletion of Bdnf in DRG neurons leads to dysregulation of miR-1.
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This points to a feedback loop between BDNF protein and its targeting miR-1.
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miR-1 regulated proteins like Hsp60 are affected by this transient dysregulation.
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Moreover, expression levels of various other miRNAs may remain permanently altered.
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This might influence the phenotype after inducible Bdnf gene deletion.