Treatment of murine lupus with PD-LIg
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- 作者：Hui Zhoua ; b ; c ; 1 ; Lijuan Xiongc ; 1 ; Yuxiao Wangc ; Li Dingb ; c ; Shi Hud ; Ming Zhaoa ; 15602239057@163.com" class="auth_mail" title="E-mail the corresponding author ; Lijun Zhoub ; c ; hzzhoulj@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD-1 ; PD-L ; Targeted therapy ; Murine lupus
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：1-8
- 全文大小：1194 K
文摘
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PD-1Ig, PD-L1Ig and PD-L2Ig were generated and characterized.
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Significantly improved survival was observed in the treatment group compared with control mice.
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PD-L1Ig treatment was most efficacious in delaying the disease process.
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Even when PD-L1Ig treatment was stop, the most advanced stage of disease was delayed.