Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents
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- 作者：Pritam Thapaa ; 1 ; Tara Man Kadayata ; 1 ; Seojeong Parkb ; Somin Shinb ; Til Bahadur Thapa Magara ; Ganesh Bista ; Aarajana Shresthaa ; Younghwa Nac ; Youngjoo Kwonb ; ykwon@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Eung-Seok Leea ; eslee@yu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-Phenol-4-chlorophenyl-6-aryl pyridines ; Cytotoxicity ; Topoisomerase I and II inhibition ; Synthesis
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：145-159
- 全文大小：909 K
文摘
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Thirty-six 2-phenol-4-chlorophenyl-6-aryl pyridines were synthesized.
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Evaluated for topo I and II inhibitory activity, and cytotoxicity.
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Compounds showed selective topo II inhibition.
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ortho- or para-Chlorophenyl at 4-position might be important for topo II inhibition.
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meta- or para-Hydroxyphenyl at 2-position showed better cytotoxic effects.