EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR
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- 作者：Mohammed Kaplan1 ; 5 ; Siddarth Narasimhan1 ; Cecilia de Heus2 ; 6 ; Deni Mance1 ; Sander van Doorn3 ; Klaartje Houben1 ; Du&scaron ; an Popov-Čeleketić2 ; Reinier Damman1 ; Eugene A. Katrukha2 ; Purvi Jain2 ; Willie J.C. Geerts4 ; Albert J.R. Heck3 ; Gert E. Folkers1 ; Lukas C. Kapitein2 ; Simone Lemeer3 ; Paul M.P. van Bergen en Henegouwen2 ; p.vanbergen@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Marc Baldus1 ; 7 ; m.baldus@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：EGFR ; NMR ; Solid-state NMR ; tyrosine kinase ; receptor ; activation ; membrane protein ; cancer
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1241-1251.e11
- 全文大小：5439 K
文摘
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NMR can be applied to study activation of full-length EGFR in native membranes
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Solid-state NMR provides insight into structure and mobility of full-length EGFR
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Data identify conformational selection as a key factor for receptor activation