Non-linear contribution of serum vitamin D to symptomatic diabetic neuropathy: A case-control study

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• 作者：Alireza Esteghamati^a ; ^{esteghamati@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Akbar Fotouhi^b ; ^{afotouhi@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Sara Faghihi-Kashani^a ; ^b ; ^{dehsarvi.sara@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nima Hafezi-Nejad^a ; ^{nimahn@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Behnam Heidari^a ; ^{bh.medstudent@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sara Sheikhbahaei^a ; ^{Shbahaei@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ali Zandieh^a ; ^{ali_zandieh3@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Manouchehr Nakhjavani^a ; ^{nakhjavanim@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Vitamin D ; Diabetes mellitus ; Toxicity ; Diabetic neuropathy
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：44-50
• 全文大小：559 K

文摘

Vitamin D deficiency has recently been speculated to be associated with increased risk of diabetes neuropathy (DN). The aim of this study was to evaluate the odds of symptomatic DN across serum vitamin D levels.

Methods

All patients with DM were assessed using diabetic neuropathy symptoms and diabetic neuropathy examination score. Overall, 150 cases with DN and 600 controls were included. Serum 25-hydroxyvitamin D (25-OH-D) was measured to determine vitamin D status.

Results

A non-linear association between 25-OH-D and suffering from symptomatic DN was observed which was extracted after stratifying the ORs across different serum 25-OH-D levels. When compared to individuals with 25-OH-D of 30–40 ng/mL, patients with deficient (<20 ng/mL) vitamin D levels had higher odds of having symptomatic DN (OR: 2.04, 95%CI: 0.99–4.02, P = 0.054). Participants with vitamin D values of greater than 40 ng/mL were also more likely to exhibit symptomatic DN (fully adjusted OR: 4.29, 95%CI: 1.59–11.55).

Conclusions

We hypothesize a non-linear contribution of serum vitamin D to symptomatic DN occurrence, which emphasizes that administration of vitamin D should be monitored and evaluated more carefully, especially in patients with diabetes.