Suppressive effects of low-dose 5-fluorouracil, busulfan or treosulfan on the expansion of circulatory neutrophils and myeloid derived immunosuppressor cells in tumor-bearing mice
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- 作者：Manuchehr Abedi-Valugerdi ; Ph.D.a ; Manuchehr.Abedi-Valugerdi@ki.se" class="auth_mail" title="E-mail the corresponding author ; Johanna Wolfsberger ; MSca ; 1 ; johanna.wolfsberger@ki.se" class="auth_mail" title="E-mail the corresponding author ; Preethi Raghuram Pillai ; MSca ; 1 ; preethi.r.pillai@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Wenyi Zheng ; MSca ; wenyi.zheng@ki.se" class="auth_mail" title="E-mail the corresponding author ; Behnam Sadeghi ; MD ; Ph.D.b ; Behnam.Sadeghi@ki.se" class="auth_mail" title="E-mail the corresponding author ; Ying Zhao ; Ph.D.a ; ying.zhao.1@ki.se" class="auth_mail" title="E-mail the corresponding author ; Moustapha Hassan ; Ph.D.a ; c ; Moustapha.Hassan@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-FU ; 5-fluorouracil ; Bu ; busulfan ; G-MDSCs ; granulocytic MDSCs ; M-MDSCs ; monocytic MDSCs ; MDSCs ; myeloid-derived suppressor cells ; Treo ; treosulfan ; WBC ; white blood cells
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：41-49
- 全文大小：902 K
文摘
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The expansion of tumor-associated neutrophils (TANs) was characterized in mice.
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Effects of low-dose 5-FU, Bu, and Treo on TANs were determined.
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TANs represent MDSCs/G-MDSCs in tumor-bearing mice.
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5-FU and Treo, but not Bu, reduce the tumor size in tumor-bearing mice.
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5-FU and Treo, but not Bu, attenuate the numbers of TANs, MDSCs and bone marrow myeloid cells in tumor-bearing mice.