Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting
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- 作者：Elisse C. Browne ; Belinda M. Abbott ; b.abbott@latrobe.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyotrophic lateral sclerosis ; Motor neurone disease ; Drug treatment ; SOD1 mouse model
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：918-925
- 全文大小：438 K
文摘
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ALS is a debilitating and ultimately fatal neurological disorder for which there is currently no cure.
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Targeting pathogenic mechanisms involved in ALS disease progression may lead to neuroprotection and an effective treatment.
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This review draws attention to recent developments for the treatment of ALS in the SOD1 transgenic mouse model.