EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
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- 作者：Benedicte Stavika ; b ; benedicte.stavik@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Sandra Espadaa ; b ; e ; s.e.serrano@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Xue Yan Cuia ; b ; d ; x.y.cui@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Nina Iversenc ; nina.iversen@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Sverre Holmb ; f ; sverre.holm@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Marie-Christine Mowinkela ; b ; uxmaow@ous-hf.no" class="auth_mail" title="E-mail the corresponding author ; Bente Halvorsenb ; d ; bente.halvorsen@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Grethe Skrettinga ; b ; grethe.skretting@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Per Morten Sandseta ; b ; d ; p.m.sandset@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tissue factor pathway inhibitor ; Hypoxia ; HIF-2α ; Atherosclerosis
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：670-678
- 全文大小：1766 K
文摘
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Hypoxia reduces tissue factor pathway inhibitor levels in endothelial cells.
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Hypoxia increases the procoagulant activity of endothelial cells.
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HIF-2alpha is involved in the hypoxia-induced reduction of tissue factor pathway inhibitor.