PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling
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- 作者：Xingfeng Liu1 ; 8 ; Jisen Huai1 ; 8 ; jisen.huai@unimedizin-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Heiko Endle1 ; 8 ; Leslie Schlü ; ter1 ; Wei Fan1 ; Yunbo Li1 ; Sebastian Richers1 ; Hajime Yurugi2 ; Krishnaraj Rajalingam2 ; Haichao Ji1 ; Hong Cheng1 ; Benjamin Rister1 ; Guilherme Horta1 ; Jan Baumgart1 ; Hendrik Berger1 ; Gregor Laube3 ; Ulrich Schmitt4 ; Michael J. Schmeisser5 ; 6 ; Tobias M. Boeckers5 ; Stefan Tenzer2 ; Andreas Vlachos7 ; 10 ; Thomas Deller7 ; Robert Nitsch1 ; 9 ; robert.nitsch@unimedizin-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Johannes Vogt1 ; 9 ; johannes.vogt@unimedizin-mainz.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：38
- 期：3
- 页码：275-290
- 全文大小：3903 K
文摘
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PRG-1 affects spine density and synaptic plasticity in a cell-autonomous fashion
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Cell-autonomous PRG-1 action is mediated via its intracellular C terminus (PRG-1CT)
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PRG-1CT acts via protein phosphatase 2A (PP2A)/ITGB1 activation
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Pharmacological ITGB1 activation restores spine density and synaptic plasticity