Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms
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- 作者：Davinia Plaa ; Benjamin W. Bandeb ; Ronelle E. Weltonc ; Owen K. Paivab ; Libia Sanza ; Á ; lvaro Segurae ; Christine E. Wrightc ; d ; Juan J. Calvetea ; jcalvete@ibv.csic.es" class="auth_mail" title="E-mail the corresponding author ; José ; Marí ; a Gutié ; rreze ; jose.gutierrez@ucr.ac.cr" class="auth_mail" title="E-mail the corresponding author ; David J. Williamsb ; c ; david.williams@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudechis papuanus ; Snake venomics ; Seqirus antivenoms ; In vivo neutralisation ; Antivenomics ; Lethality ; Myotoxicity
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：201-215
- 全文大小：2030 K
文摘
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The proteomic and toxicological profiles of the Papuan black snake venom were investigated.
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P. papuanus venom induced intravascular hemolysis, pulmonary edema, anticoagulation, and death.
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P. papuanus venom proteome is dominated (90%) by a variety (n ≥ 18) of PLA2s.
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Toxic activities of P. papuanus venom in mice were mainly due to the action of its PLA2 molecules.
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Australian black snake and polyvalent antivenoms were effective in neutralising the toxic activities of P. papuanus venom.