Visual and fluorescent assays for selective detection of beta-amyloid oligomers based on the inner filter effect of gold nanoparticles on the fluorescence of CdTe quantum dots
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- 作者：Ning Xia ; Binbin Zhou ; Nanbing Huang ; Mengsha Jiang ; Jiebing Zhang ; Lin Liu ; liulin@aynu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Beta-amyloid ; Inner filter effect ; Fluorescent biosensor ; Visual assay ; Quantum dots ; Gold nanoparticles
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：625-632
- 全文大小：1546 K
文摘
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We reported a visual/fluorescent method for assay of beta-amyloid oligomers (AβOs).
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It was based on the inner filter effect of AuNPs on the fluorescence of quantum dots.
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AβOs-specific binding peptide triggered the aggregation and color change of AuNPs.
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It shows excellent selectivity to AβOs but not monomers (AβMs) and fibrils (AβFs).
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The detection limits were 0.5 nM for visual assay and 0.2 nM for fluorescent assay.