Selenium deficiency induced damages and altered expressions of metalloproteinases and their inhibitors (MMP1/3, TIMP1/3) in the kidneys of growing rats

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• 作者：Jing Han^a ; ¹ ; ^{bbbishop@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hua Liang^b ; ¹ ; ^{lianghua001@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jianhua Yi^a ; ^{laowei@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wuhong Tan^a ; ^{tanwh@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Shulan He^c ; ^{heshulan0954@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaofang Wu^a ; ^{1028294561@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaowei Shi^d ; ^{shilixiaowei@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jing Ma^e ; ^{mjdjw@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiong Guo^a ; ^{guox@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Selenium deficiency ; Kidney ; Damage ; MMP ; TIMP
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：34
• 期：Complete
• 页码：1-9
• 全文大小：5984 K

文摘

Selenium is an essential trace element for the maintenance of structures and functions of kidney. To evaluate the effects of low selenium on the kidneys of growing rats, newborn rats were fed with selenium deficient and normal diets respectively for 109 days. As a result, rats fed with low selenium diets resulted in a decline in the body weight and the concentration of selenium in the kidney, especially the male rats from the low selenium groups. Moreover, the ultrastructure of glomerulus and tubules were damaged in low selenium group: the glomeruli were observed with hyperplasia of mesangial cells, fusion of podocyte foot processes and thickening of basement membrane; and the tubules were observed with vacuolar degenerated epithelial cells, increased edema fluid or protein solution between cells, microvilli edema, increased cell gaps and decreased cell links. Furthermore, the pathological changes in selenium deficient group included the increase of fibers around renal hilum aorta and in the renal collecting duct, and shed of cells in the proximal convoluted tubules. In addition, up-regulated expressions of matrix metalloproteinases (MMP1/3) and down-regulated expressions of their inhibitors (TIMP1/3) at the mRNA and protein levels were also appeared to be relevant to low selenium. The results suggested that low selenium in diet may cause low selenium concentration in the kidney of growing rat and lead to damages of the ultrastructure and extracellular matrix (ECM) of kidney.