Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects
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- 作者：Haley R. Eidema ; haley.eidem@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; David C. Rinkera ; b ; david.rinker@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; William E. Ackerman IVc ; william.ackerman@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Irina A. Buhimschid ; irina.buhimschi@nationwidechildrens.org" class="auth_mail" title="E-mail the corresponding author ; Catalin S. Buhimschic ; catalin.buhimschi@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Caitlin Dunn-Fletchere ; caitlin.dunn@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Suhas G. Kallapurd ; suhas.kallapur@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Mihaela Pavličeve ; mihaela.pavlicev@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Louis J. Mugliae ; louis.muglia@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Patrick Abbota ; patrick.abbot@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Antonis Rokasa ; b ; antonis.rokas@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pregnancy ; Placenta ; Preterm birth ; Gestational age ; RNA sequencing ; Transcriptomics
- 刊名：Placenta
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：74-82
- 全文大小：538 K
文摘
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Ethical issues prevent collection of appropriate control tissues in studies of human spontaneous preterm birth (sPTB).
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Gestational age (GA) controls from closely related species allow for the identification of human sPTB- and GA-specific genes.
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We compared transcriptomes from human preterm, human term, and healthy GA-matched macaque placentas.
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Our novel, comparative approach identified 29 sPTB- and 37 GA-specific genes as promising candidates for future research.