Comprehensive RNA profiling of villous trophoblast and decidua basalis in pregnancies complicated by preterm birth following intra-amniotic infection
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- 作者：William E. Ackerman IVa ; william.ackerman@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Irina A. Buhimschib ; irina.buhimschi@nationwidechildrens.org" class="auth_mail" title="E-mail the corresponding author ; Haley R. Eidemc ; haley.eidem@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; David C. Rinkerd ; david.rinker@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Antonis Rokasc ; d ; antonis.rokas@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Kara Rooda ; kara.rood@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Guomao Zhaob ; lisa.zhao@nationwidechildrens.org" class="auth_mail" title="E-mail the corresponding author ; Taryn L. Summerfielda ; taryn.summerfield@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Mark B. Landona ; mark.landon@osumc.edu" class="auth_mail" title="E-mail the corresponding author ; Catalin S. Buhimschia ; catalin.buhimschi@osumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preterm birth ; Placenta ; Infection ; RNA-sequencing ; Transcriptomics ; microRNA
- 刊名：Placenta
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：23-33
- 全文大小：2008 K
文摘
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The placental response to intra-amniotic infection was profiled using RNA-seq.
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Intra-amniotic infection markedly altered the villous trophoblast transcriptome.
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This transcriptional signature suggested an acute inflammatory infiltrate.
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Intra-amniotic infection modestly changed the decidua basalis transcriptome.
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Regional differences in placental RNA expression were determined.