Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints
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- 作者：Karl Edman1 ; karl.edman@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author ; Ali Hosseini2 ; Magnus K. Bjursell3 ; Anna Aagaard1 ; Lisa Wissler1 ; Anders Gunnarsson1 ; Tim Kaminski1 ; Christian Kö ; hler4 ; Stefan Bä ; ckströ ; m1 ; Tina J. Jensen4 ; Anders Cavallin4 ; Ulla Karlsson1 ; Ewa Nilsson1 ; Daniel Lecina2 ; Ryoji Takahashi2 ; Christoph Grebner5 ; Stefan Geschwindner1 ; Matti Lepistö ; 4 ; Anders C. Hogner5 ; anders.hogner@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author ; Victor Guallar2 ; 6 ; victor.guallar@bsc.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：23
- 期：12
- 页码：2280-2290
- 全文大小：3853 K
文摘
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X-Ray structures of MR and GR reveal a conserved plasticity near helices 6 and 7
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Ligand binding simulations provide a functional role to the observed plasticity
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Residence time measurements correlate with the proposed binding mechanism
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Differences in receptor blueprints promote differential evolutionary constraints