MicroRNAs are associated with blood-pressure effects of exposure to particulate matter: Results from a mediated moderation analysis
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- 作者：Valeria Mottaa ; valeria.motta@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Chiara Faveroa ; chiara.favero@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Laura Dionia ; laura.dioni@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Simona Iodicea ; simona.iodice@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Cristina Battagliab ; laura.angelici@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Laura Angelicia ; laura.angelici@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Luisella Vignac ; luisella.vigna@policlinico.mi.it" class="auth_mail" title="E-mail the corresponding author ; Angela Cecilia Pesatoria ; d ; angela.pesatori@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Valentina Bollatia ; valentina.bollati@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：CVD ; Cardiovascular disease ; BP ; Blood pressure ; PM ; Particulate matter ; PM10 ; PM of less than 10 ; μm in aerodynamic diameter ; miRNAs ; MicroRNAs ; MI ; Myocardial infarction ; BMI ; Body mass index ; CIE ; Conditional indirect effect ; FARM ; Flexible Air Quality Regional Model ; TLDA ; TaqMan Low-Density Array ; FDR ; False Discovery Rate ; IPA ; Ingenuity Pathway Analysis
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：274-281
- 全文大小：1084 K
文摘
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We investigated whether the effects of PM10 on BP are mediated by microRNAs.
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PM10 exposure was associated with increased systolic and diastolic BP.
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Nine blood miRNAs were associated with PM10 levels 48 h after exposure.
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miR-101 mediated the effects of particle exposure on diastolic BP.