Part-1: Design, synthesis and biological evaluation of novel bromo-pyrimidine analogs as tyrosine kinase inhibitors
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- 作者：Chandrashekar Suradhenupura Munikrishnappaa ; chandrajan25@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sangamesh B. Puranikb ; sangpur@rediffmail.com" class="auth_mail" title="E-mail the corresponding author ; G.V. Suresh Kumarb ; sureshkumargv@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Y. Rajendra Prasadc ; dryrp_au@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-Bromo-pyrimidine ; Anticancer ; Dasatinib derivatives ; Cytotoxicity ; MTT assay
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：70-82
- 全文大小：2252 K
文摘
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Dasatinib based novel bromo-pyrimidine derivatives have been designed and synthesized.
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The cytotoxic activities of the compounds against cancer cell lines were evaluated.
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The compounds were screened for Bcr/Abl tyrosine kinase inhibitory.
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The compounds are promising leads to be developed as an alternative for Dasatinib therapy.