Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice
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- 作者：Daniel J. Minnemaa ; daniel.minnema@syngenta.com" class="auth_mail" title="E-mail the corresponding author ; Kim Z. Travisb ; kim.travis@syngenta.com" class="auth_mail" title="E-mail the corresponding author ; Charles B. Breckenridgea ; charles.breckenridge@syngenta.com" class="auth_mail" title="E-mail the corresponding author ; Nicholas C. Sturgessb ; nick.sturgess@syngenta.com" class="auth_mail" title="E-mail the corresponding author ; Mark Buttc ; mbutt@toxpath.net" class="auth_mail" title="E-mail the corresponding author ; Jeffrey C. Wolfd ; jwolf@epl-Inc.com" class="auth_mail" title="E-mail the corresponding author ; Dan Zadoryd ; dzadory@epl-Inc.com" class="auth_mail" title="E-mail the corresponding author ; Mark T. Herberthe ; mark.herberth@wilresearch.com" class="auth_mail" title="E-mail the corresponding author ; Scott L. Watsonf ; slwatson@rti.org" class="auth_mail" title="E-mail the corresponding author ; Andrew R. Cookb ; andy.cook@syngenta.com" class="auth_mail" title="E-mail the corresponding author ; Philip A. Bothamb ; phil.botham@syngenta.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diquat ; C57BL/6J mice ; Dopamine ; Substantia nigra ; MPTP
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：81-88
- 全文大小：2574 K
文摘
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Mice provided diquat dibromide in their diets for 13 weeks did not exhibit insult to the nigrostriatal dopaminergic system.
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MPTP-treated mice exhibited decreased striatal dopamine, reduced numbers of SNpc TH+ neurons and neuropathological changes.
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Nigrostriatal dopaminergic system insult was assessed using neurochemical, neuropathological and stereological endpoints.