Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis
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- 作者：Aniruddha Chatterjeea ; b ; aniruddha.chatterjee@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Malgorzata Lagiszc ; d ; m.nakagawa-lagisz@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Euan J. Rodgera ; b ; euan.rodger@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Li Zhene ; liz10@gis.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Peter A. Stockwellf ; peter.stockwell@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Elizabeth J. Duncanf ; elizabeth.duncan@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Julia A. Horsfielda ; b ; julia.horsfield@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Justin Jeyakanie ; gnanakkan@gis.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Sinnakaruppan Mathavane ; mathavans@ntu.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Yuichi Ozakig ; yuichi.ozaki@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Shinichi Nakagawac ; d ; h ; s.nakagawa@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：DMCs ; differentially methylated CpG sites ; RRBS ; reduced representation bisulfite sequencing ; FDR ; False Discovery Rate
- 刊名：Gene
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：590
- 期：2
- 页码：307-316
- 全文大小：873 K
文摘
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The global DNA methylation profile of male and female zebrafish brain is similar.
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Site-specific methylation differences exist between adult male and female brain.
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Distinct CpG clusters are differentially methylated between male and female brain.
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Differentially methylated CpGs are enriched in gene body, intergenic regions.
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More female-biased genes are expressed than male-biased genes in zebrafish brain.