l-Proline and thiourea co-catalyzed condensation of acetone

详细信息    查看全文

• 作者：Lin Xu^a ; ^b ; ^c ; Fang Wang^d ; Jiejun Huang^b ; ^c ; Chenggen Yang^c ; Lei Yu^a ; ^b ; ^c ; ^{yulei@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yining Fan^a ; ^{ynfan@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Organocatalysis ; Acetone condensation ; l-Proline ; Thiourea ; Green synthesis
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 July 2016
• 年：2016
• 卷：72
• 期：27-28
• 页码：4076-4080
• 全文大小：767 K

文摘

Amino acid and primary amine/amide co-catalyzed acetone condensation was investigated. It was found that class="smallcaps">l-proline had overwhelming catalytic activity over other amino acids as well as the analogues with similar structures. Surprisingly, thiourea, a very cheap and stable chemical, was found to be the favorable co-catalyst. Co-catalyzed by the recyclable class="smallcaps">l-proline and thiourea, condensation of acetone led to the useful products mesityl oxide (MO), diacetone alcohol (DAA) and isophorone (IP) in the excellent 96.3% total selectivity.