Fabrication of folic acid-sensitive gold nanoclusters for turn-on fluorescent imaging of overexpression of folate receptor in tumor cells
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- 作者：Hongchang Lia ; b ; 1 ; Yuqing Chenga ; b ; 1 ; Yong Liua ; b ; Bo Chena ; b ; dr-chenpo@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Folic acid-sensitive ; BSA-AuNCs ; Fluorescence imaging ; Folate receptor expressed tumor cells
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：118-124
- 全文大小：1221 K
文摘
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BSA-AuNCs emit red light that offer improved tissue penetration depth and negligible fluorescence background.
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FA can interact with BSA, leading to fluorescence intensity quenching of BSA-AuNCs.
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FA@BSA-AuNCs nanocomposite as a turn-on probe can be used for imaging of FR overexpressed tumor cells.
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The probe with “off-on” mechanism can avoid false positive results.