Facile “one-pot” synthesis of poly(methacrylic acid)-based hybrid monolith via thiol-ene click reaction for hydrophilic interaction chromatography
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A poly (methacrylic acid)-based hybrid monolith was fabricated via radical-mediated thiol-ene click reaction.

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The modification of monolith was achieved via a “one-step” process.

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The obtained monolith was provided with uniform porous structure and good permeability.

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A typical HILIC separation behavior was observed and the BSA digest was well separated.

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