Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex
详细信息 查看全文
- 作者：Darius Ebrahimi-Fakhari1 ; 2 ; 6 ; Afshin Saffari1 ; 2 ; 6 ; Lara Wahlster2 ; 3 ; Alessia Di Nardo1 ; Daria Turner1 ; Tommy L. Lewis Jr.4 ; Christopher Conrad5 ; Jonathan M. Rothberg5 ; Jonathan O. Lipton1 ; Stefan Kö ; lker2 ; Georg F. Hoffmann2 ; Min-Joon Han1 ; Franck Polleux4 ; Mustafa Sahin1 ; 7 ; mustafa.sahin@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：mTOR ; mTORC1 ; autophagy ; mitochondria ; autism ; axonal transport ; synapse ; lysosome ; rapamycin ; carbamazepine
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1053-1070
- 全文大小：6210 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Mitochondria, some of which are dysfunctional, accumulate in Tsc2-deficient neurons
- class="label">•
Axonal mitochondria, including those captured at presynaptic sites, are depleted
- class="label">•
Spatiotemporal dynamics of axonal mitophagy and global mitophagic flux are impaired
- class="label">•
Enhancing mTOR-dependent and -independent autophagy restores mitochondrial turnover