Dielectric functionalization for differential phase detecting localized surface plasmon resonance biosensor
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- 作者：Guangyu QiuAuthor Vitae ; Siu Pang NgAuthor Vitae ; Lawrence Chi-Man Wu ; lawrence.wu@cityu.edu.hk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Dielectric functionalization ; Nanoislands ; Differential phase detecting ; Localized surface plasmon ; Immunoassay biosensor
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：29 October 2016
- 年：2016
- 卷：234
- 期：Complete
- 页码：247-254
- 全文大小：2012 K
文摘
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A novel dielectric functionalization approach has been developed for LSPR immunosensing.
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General functionalization protocol for label-free biosensors with dielectric substrate.
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Enhancement of localized electric field between two adjacent nanoislands is studied by FDTD modeling.
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High sensitivity for detection of human IgG antigen from 1 pM to 100 pM with dielectric functionalized LSPR biosensors.
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Quantitative detection of human IgG antigen in human serum with high specificity.