Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression, and DNA methylation of the Bdnf gene
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- 作者：Rachel L. Millera ; b ; c ; Rlm14@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Zhonghai Yana ; zy2167@columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Christina Mahera ; cemmaher@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hanjie Zhanga ; hanjiezhangydx@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kathryn Gudsnukd ; kmg2143@columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Jacob McDonalde ; jmcdonal@lrri.org" class="auth_mail" title="E-mail the corresponding author ; Frances A. Champagned ; fac2105@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polycyclic aromatic hydrocarbons ; Open-field testing ; Brain-derived neurotrophic factor ; Novel object test ; N-methyl d-aspartate 2B ; DNA methylation
- 刊名：Neuroepigenetics
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：11-18
- 全文大小：651 K
文摘
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Prenatal PAH–exposed offspring spent more time immobile and less time exploring an open field.
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Prenatal PAH–exposed females produced more fecal boli during open-field testing.
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Prenatal PAH–exposed males failed to exhibit a preference for a novel object.
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Prenatal PAH–exposed males exhibited reduced cortical expression of Grin2b and Bdnf.
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Prenatal PAH–exposed offspring exhibited elevated DNA methylation in Bdnf IV.