Chitosan gel-embedded moxifloxacin niosomes: An efficient antimicrobial hybrid system for burn infection
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- 作者：Shohreh Sohrabi ; Azadeh Haeri ; Arash Mahboubi ; Alireza Mortazavi ; Simin Dadashzadeh ; Sdadashzadeh@sbmu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; dadashzadeh5@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan gel ; Niosomes ; Moxifloxacin
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：625-633
- 全文大小：1626 K
文摘
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A niosome-in-chitosan gel hybrid system for topical moxifloxacin delivery is proposed.
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The moxifloxacin niosomal gel systems exhibited sustainable release behaviors.
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The hybrid system showed adequate bioadhesiveness and pseudo-plastic flow behavior.
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Niosomal formulation showed a higher antibacterial activity against P. aeruginosa.
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Chitosan gels markedly enhanced the efficacy of moxifloxacin against S. aureus.