Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study
详细信息 查看全文
- 作者：Fernando Carcellera ; b ; Fernando.Carceller@icr.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Francisco J. Bautistac ; 1 ; franciscojose.bautista@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author ; Irene Jimé ; neze ; irene.jimenez@curie.fr" class="auth_mail" title="E-mail the corresponding author ; Raquel Hladun-Á ; lvaroc ; 2 ; rhladun@vhebron.net" class="auth_mail" title="E-mail the corresponding author ; Cé ; cile Giraudf ; g ; cecile.giraud@lyon.unicancer.fr" class="auth_mail" title="E-mail the corresponding author ; Luca Bergamaschih ; Luca.Bergamaschi@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Madhumita Dandapanii ; Madhumita.Dandapani@bch.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Isabelle Aertse ; isabelle.aerts@curie.fr" class="auth_mail" title="E-mail the corresponding author ; Franç ; ois Doze ; j ; francois.doz@curie.fr" class="auth_mail" title="E-mail the corresponding author ; Didier Frappazf ; g ; didier.frappaz@ihope.fr" class="auth_mail" title="E-mail the corresponding author ; Michela Casanovah ; Michela.Casanova@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Bruce Morlandi ; BRUCE.MORLAND@bch.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Darren R. Hargravek ; Darren.Hargrave@gosh.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Lynley V. Marshalla ; b ; LynleyVanessa.Marshall@icr.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Gilles Vassall ; Gilles.Vassal@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author ; Andrew D.J. Pearsona ; b ; 3 ; andy1pearson@btinternet.com" class="auth_mail" title="E-mail the corresponding author ; Birgit Geoergerc ; Birgit.GEOERGER@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author ; Lucas Morenod ; lmorenom@ext.cnio.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prognostic factor ; Survival ; Children ; Adolescents ; Dose-finding trial ; Phase I trial ; Innovative Therapies for Children with Cancer
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：130-140
- 全文大小：759 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
We assessed prognostic factors of overall survival (OS) in 248 children and adolescents enrolled in 21 phase I trials between 2000–2014.
- class="label">•
Performance status of 90–100% and school/work attendance at enrolment were strong indicators of longer OS.
- class="label">•
Adult predictive scores (RMH and MDACC) correlated with survival in adolescents (12–17 years), but not in children (2–11 years).
- class="label">•
These findings may orientate about potential prognoses and could lead to paediatric-adapted eligibility criteria in early phase trials.