Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients
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- 作者：Ekaterina A. Semenova1 ; 10 ; Min-chul Kwon1 ; 10 ; Kim Monkhorst2 ; 10 ; Ji-Ying Song3 ; Rajith Bhaskaran1 ; 8 ; Oscar Krijgsman5 ; Thomas Kuilman5 ; Dennis Peters4 ; Wieneke A. Buikhuisen6 ; Egbert F. Smit6 ; Colin Pritchard7 ; Miranda Cozijnsen1 ; Jan van der Vliet1 ; John Zevenhoven1 ; Jan-Paul Lambooij1 ; Natalie Proost1 ; Erwin van Montfort1 ; Arno Velds8 ; Ivo J. Huijbers7 ; 11 ; i.huijbers@nki.nl" class="auth_mail" title="E-mail the corresponding author ; Anton Berns1 ; 9 ; 11 ; a.berns@nki.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：631-643
- 全文大小：6045 K
文摘
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NFIB drives tumor initiation and progression in mouse models of SCLC
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NFIB enhances metastasis and changes the metastatic profile
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NFIB promotes dedifferentiation and invasion in SCLC
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NFIB marks stage III/IV high-grade neuroendocrine carcinomas in patients