Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells
详细信息 查看全文
- 作者：Vanathi Perumala ; 1 ; Sebastian Pohlb ; 1 ; Kevin N. Keanec ; 1 ; Frank Arfusob ; Philip Newsholmec ; Simon Foxa ; Arun Dharmarajanb ; a.dharmarajan@curtin.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesothelioma ; Wnt ; Secreted frizzled-related protein 4 ; Metabolism
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：341
- 期：2
- 页码：218-224
- 全文大小：1372 K
文摘
- class="listitem" id="list_li0005">
- class="label">•
Secreted frizzled-related protein 4 reduces mesothelioma cell proliferation.
- class="label">•
Secreted frizzled-related protein 4 induces mesothelioma cell death.
- class="label">•
Secreted frizzled-related protein 4's effects differ depending on the time course.
- class="label">•
Secreted frizzled-related protein 4 interacts with Wnt3a in mesothelioma cells.
- class="label">•
Secreted frizzled-related protein 4 has a biphasic effect on GSK3-β phosphorylation.