Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells
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- 作者：Yan Zhoua ; b ; 1 ; Yuan Lib ; 1 ; Hong-Min Nib ; Wen-Xing Dingb ; Hua Zhonga ; eddiedong8@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CQ ; Chloroquine ; EGFR ; Epidermal growth factor receptor ; EM ; Electron microscopy ; Gef ; Gefitinib ; Ico ; Icotinib ; Keap1 ; Kelch-like ECH-associated protein 1 ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; NSCLC ; Non-small cell lung cancer ; Nrf2 ; NF-E2-related factor 2 ; TKI ; Tyrosine kinase inhibitor ; ULK1 ; Unc-51 like kinase 1
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：140-149
- 全文大小：2765 K
文摘
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Cancer cells use adaptive mechanisms against chemotherapy.
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Autophagy is not essential for the drug resistance of lung cancer A549 cells.
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Inhibition of Nrf2 decreases cell survival of lung cancer A549 cells.