Systemically Transplanted Bone Marrow-derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model
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- 作者：Wenan Xu ; DDS ; PhD&lowast ; ; &dagger ; ; Shan Jiang ; MD ; PhD&Dagger ; ; Qiuyue Chen ; MS&lowast ; ; Yanyan Ye ; MS§ ; ; Jiajing Chen ; MS&lowast ; ; Boon Chin Heng ; PhD‖ ; Qianli Jiang ; MD ; PhD§ ; ; Buling Wu ; DDS ; PhD&lowast ; ; bulingwu0605@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Zihai Ding ; MD ; PhD&dagger ; ; dingzih@163.com" class="auth_mail" title="E-mail the corresponding author ; Chengfei Zhang ; DDS ; PhD‖ ; ¶ ; ; zhangcf@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone marrow&ndash ; derived cells ; chimeric mouse ; in vivo imaging ; pulp regeneration
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：42
- 期：2
- 页码：263-268
- 全文大小：1165 K
文摘
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A chimeric mouse model was created through the injection of bone marrow cells from GFP transgenic C57BL/6 mice into the tail veins of recipient wild-type C57BL/6 mice.
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This chimeric mouse model was subjected to pulpectomy and pulp revascularization to study the process in which bone marrow derived cells were involved in revascularization of pulp tissue.
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Dynamic fluorescence imaging in vivo and immunofluorescence were used to explore mechanisms of bone marrow derived cells involved in the process of pulp revascularization.