Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc
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- 作者：Aiqun Weia ; Bojiang Shena ; Lisa A. Williamsa ; Divya Bhargava ; Feng Yanb ; Beng H. Chongb ; Ashish D. Diwana ; a.diwan@spine-service.org" class="auth_mail" title="E-mail the corresponding author ; a.diwan@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intervertebral disc ; Estrogen receptor ; GPR30 ; GPER ; Nucleus pulposus
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：46-55
- 全文大小：3521 K
文摘
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GPR30 is expressed in nucleus pulposus of human intervertebral disc.
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GPR30 is expressed in human fetal nucleus pulposus at 12–14 weeks of gestation.
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Both GPR30 and ER are required for E2 mediated NP cell proliferation and survival.