Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies
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- 作者：Radu Tanasescua ; c ; 1 ; 2 ; William J. Cottamb ; c ; 1 ; Laura Condonb ; c ; Christopher R. Tencha ; 1 ; Dorothee P. Auerb ; c ; 1 ; dorothee.auer@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chronic pain ; fMRI ; Coordinate based meta-analysis ; Hyperalgesia ; Neural pain signature
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：120-133
- 全文大小：2539 K
文摘
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Neural maladaptation in chronic pain conditions is poorly understood.
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Large scale coordinate based meta-analysis of 266 cutaneous pain fMRI was performed.
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Results support a shared neural pain response in chronic pain and healthy subjects.
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Hyperalgesia leads to increased activation in an unchanged neural pattern.
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Chronic pain patients show functional reorganisation depending on stimulation site.