In healthy subjects, quadripulse transcranial magnetic stimulation (QPS) over the primary motor cortex (M1) induces bidirectional heterotopic plasticity in the somatosensory cortex (S1), following the Bienenstock–Cooper–Munro (BCM)-like theory.
In patients with benign myoclonus epilepsy (ME patients), QPS over M1 induces long-term potentiation (LTP) but no long-term depression (LTD) in S1.
QPS is not applicable to the treatment for ME patients because the frequency dependency may be completely different between the healthy subjects and the patients.