Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers
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- 作者：Alejandro Gomez-Aulia ; b ; c ; Larissa Elisabeth Hillebranda ; c ; d ; Martin Lothar Biniosseka ; Christoph Petersa ; d ; e ; Thomas Reinheckela ; d ; e ; Oliver Schillinga ; d ; e ; oliver.schilling@mol-med.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Interstitial fluid ; Proteomics ; Tumor microenvironment ; Cathepsins ; Ectodomain shedding ; Proteases
- 刊名：Biochimie
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：88-98
- 全文大小：2394 K
文摘
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Tumor interstitial fluid of mice with altered cathepsin B expression were analyzed.
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High content of protease and protease inhibitors was observed.
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Abundant shed ectodomains highlights the proteolysis in tumor–stroma interaction.
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Cathepsin B acts on the abundance of alpha-1B-glycoprotein and MUP 11 and 8.
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Interstitial fluid is a primary source for the anaylsis of cancer secretomes.