Ultra-high-pressure liquid chromatography tandem mass spectrometry determination of antidepressant and anxiolytic drugs in neonatal meconium and maternal hair
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- 作者：Simona Pichinia ; simona.pichini@iss.it" class="auth_mail" title="E-mail the corresponding author ; Laura Cortesb ; c ; d ; lcortes@hsjdbcn.org" class="auth_mail" title="E-mail the corresponding author ; Emilia Marcheia ; emilia.marchei@iss.it" class="auth_mail" title="E-mail the corresponding author ; Renata Soliminia ; renata.solimini@iss.it" class="auth_mail" title="E-mail the corresponding author ; Roberta Pacificia ; roberta.pacifici@iss.it" class="auth_mail" title="E-mail the corresponding author ; Mª ; Dolores Gomez-Roigb ; c ; d ; lgomezroig@hsjdbcn.org" class="auth_mail" title="E-mail the corresponding author ; Oscar Garcí ; a-Algarc ; e ; 90458@hospitaldelmar.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antidepressants drugs ; Anxiolytic drugs ; Hair ; Meconium ; Ultra-high-pressure liquid chromatography tandem mass spectrometry
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：9-16
- 全文大小：914 K
文摘
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Antidepressants and anxiolytic drugs were investigated in hair and meconium samples to assess fetal exposure following gestational consumption.
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Ultra-high-pressure liquid chromatography tandem mass spectrometry assay was developed for purpose.
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Fast and simple hair and meconium extraction was applied.
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Positivity to antidepressants and anxiolytic drugs in maternal hair segments corresponded to positivity in meconium samples.