Sleep reverts changes in human gray and white matter caused by wake-dependent training
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Wake-dependent brain changes were explored using structural MRI and DWI.

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Intensive, prolonged task practice is associated with changes in structural indices.

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Sleep reverts brain structural changes caused by wake-dependent training.

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Structural alterations can predict cognitive performance at the individual level.

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Sleep may counteract performance deficits through effects on brain microstructure.

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