Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion
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- 作者：Laurent Perrin1 ; Ursula Loizides-Mangold1 ; 6 ; Svetlana Skarupelova1 ; 6 ; Pamela Pulimeno1 ; Stephanie Chanon2 ; Maud Robert3 ; Karim Bouzakri4 ; Christine Modoux5 ; Pascale Roux-Lombard5 ; Hubert Vidal2 ; Etienne Lefai2 ; Charna Dibner1 ; Charna.Dibner@hcuge.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circadian clock ; Human skeletal myotube ; Myokine ; Interleukin-6 ; Circadian bioluminescence recording
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：4
- 期：11
- 页码：834-845
- 全文大小：1506 K
文摘
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Human skeletal myotubes possess a self-sustained circadian clock.
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IL-6 secretion is strongly downregulated upon muscle clock disruption.
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The basal secretion of several myokines displays a circadian profile.
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Disruption of the circadian clock affects basal myokine secretion.