First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil

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• 作者：Guilherme A. Calvet^a ; ^{guilherme.calvet@ini.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Ana Maria B. Filippis^b ; ¹ ; ^{abispo@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Marcos Cesar L. Mendonç ; a^b ; ¹ ; ^{marcosclm@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Patricia C. Sequeira^b ; ¹ ; ^{patricia@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Andre M. Siqueira^a ; ^{andre.siqueira@ini.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Valdilea G. Veloso^c ; ^{valdilea.veloso@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Rita M. Nogueira^b ; ^{rita@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; Patrí ; cia Brasil^a ; ^{patricia.brasil@ini.fiocruz.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Zika ; ZIKV ; Arbovirus ; HIV ; Brazil
• 刊名：Journal of Clinical Virology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：74
• 期：Complete
• 页码：1-3
• 全文大小：416 K

文摘

Since May 2015, Brazil’s Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV) in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. The association between HIV infection and endemic diseases has been described especially in tropical regions with varying levels of complications, although there has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case of laboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved with only mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysis of the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge, this is the first time that Zika virus co-infection is reported in a HIV-infected patient.