Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes
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- 作者：Marcela L. Moreiraa ; marcela.moreira@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Christiane Costa-Pereiraa ; christianecosta@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Marina Luiza Rodrigues Alvesb ; marinarod.bio@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bruno H. Marteletoa ; brunomarteleto@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Vitor M. Ribeiroc ; vitor@pucminas.br" class="auth_mail" title="E-mail the corresponding author ; Vanessa Peruhype-Magalhã ; esa ; vanessa@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Rodolfo C. Giunchettib ; giunchetti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Olindo A. Martins-Filhoa ; oamfilho@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Má ; rcio S.S. Araú ; joa ; sobreira@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vaccine ; Leishmune® ; Canine leishmaniosis ; Leishmania infantum ; Phagocytosis ; TLRs ; Cytokines
- 刊名：Veterinary Parasitology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：220
- 期：Complete
- 页码：33-45
- 全文大小：1699 K
文摘
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The use of a canine protective vaccine would be an important control tool to canine leismaniosis.
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The vaccination employing Leishmune® induces in neutrophils and monocytes increase in phagocytic activity and NO production.
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The vaccination induces increased expression of TLR in neutrophils and monocytes from dogs.
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The vaccination induces preferentially inflammatory profile of cytokines.