Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells
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- 作者：Emanuela Michelia ; 1 ; Alessandro Altierib ; 1 ; Lorenzo Ciannib ; Chiara Cingolanic ; Sara Iachettinic ; Armandodoriano Biancob ; Carlo Leonettid ; Stefano Cacchionea ; Annamaria Biroccioc ; Marco Franceschinb ; marco.franceschin@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Angela Rizzoc ; angela.rizzo@ifo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：G-quadruplex ; Binding affinity ; Oncogene promoters
- 刊名：Biochimie
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：223-231
- 全文大小：1409 K
文摘
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EMICORON stabilizes the G4 structures within the c-MYC and BCL2 promoter sequences.
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EMICORON reduces both c-MYC and BCL2 expression levels in tumor cells.
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EMICORON may act as a multimodal antineoplastic drug.