The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson’s disease
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- 作者：Julia Gerstenberger julia.gerstenberger@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Anne Bauer anne.bauer@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Christin Helmschrodt christin.helmschrodt@uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Angelika Richter ; angelika.richter@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Franziska Richter ; franziska.richter@vmf.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thy1-aSyn ; mice overexpressing human wildtype alpha-synuclein under the Thy-1 promoter ; ARB ; adaptive rotating beam ; rpm ; rotation per minute ; DA ; dopamine ; SN ; substantia nigra
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：102-110
- 全文大小：1524 K
文摘
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Female Thy1-aSyn mice express less human alpha-synuclein compared to males.
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This could be involved in the lack of motor deficits in female Thy1-aSyn mice.
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A novel beam test reveals sensorimotor deficits in female Thy1-aSyn mice.
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This supports the importance of sensorimotor integration in movement disorders.
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Thy1-aSyn mice can be used to study the mechanisms of sensorimotor impairments.