Leptin dose-dependently decreases atherosclerosis by attenuation of hypercholesterolemia and induction of adiponectin
详细信息 查看全文
- 作者：Annett Hoffmanna ; Thomas Eberta ; b ; Nora Klö ; tingb ; Janine Dokasc ; Franziska Jerominc ; Beate Jessnitzera ; Ralph Burkhardtc ; Mathias Fasshauera ; b ; 1 ; Susan Kralischa ; b ; 1 ; susan.kralisch@medizin.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adiponectin ; Adipokine ; Atherosclerosis ; Insulin resistance ; Leptin ; Obesity
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1862
- 期：1
- 页码：113-120
- 全文大小：899 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
Leptin dose-dependently diminishes atherosclerosis in LDLR−/−;ob/ob mice.
- class="label">•
Leptin decreases atherogenesis through reduction of hypercholesterolemia.
- class="label">•
Leptin mediates its antiatherogenic effects through adiponectin upregulation.