This paper presents the challenges, the approach and an overview of the results of the EU-FP7 funded project Apps4aME (GA N° 314156) and provides a concise overview over the Engineering Apps (eApps) approach that the project is based on. The project aims at the comprehensive consideration of ICT-based support of Manufacturing Engineering in all the above mentioned domains, called advanced Manufacturing Engineering (aME). The different life cycles are aligned by the development of a Reference Data Model that provides a detailed overview of all relevant domain-specific and inter-domain interdependencies. This life cycle-oriented model enables an integrated product design, process development, factory planning as well as production planning and factory operation. All stakeholders in these activities are supported by eApps that are conceived, developed and validated with the help of four industrial use cases spanning very diverse industrial branches.