Alterations of the exo- and endometabolite profiles in breast cancer cell lines: A mass spectrometry-based metabolomics approach
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- 作者：Lucas Willmanna ; b ; lucas.willmann@mail.zbsa.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Manuel Schlimperta ; b ; c ; manuel.schlimpert@sgbm.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Marc Hirschfeldd ; e ; f ; marc.hirschfeld@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Thalia Erbesg ; thalia.erbes@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Hans Neubauerh ; Hans.Neubauer@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Elmar Stickeleri ; estickeler@ukaachen.de" class="auth_mail" title="E-mail the corresponding author ; Bernd Kammerera ; Bernd.Kammerer@zbsa.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metabolomics ; Breast cancer ; Quadrupole time-of-flight ; Liquid chromatography ; Mass spectrometry
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：925
- 期：Complete
- 页码：34-42
- 全文大小：1823 K
文摘
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Different extraction procedures have been applied for exo- and endometabolome.
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Cell line analysis was performed by untargeted LC-Q-TOF MS as well as targeted LC-QqQ MS.
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An UPLC-ESI-Q-TOF method based on a scheduled precursor list was established for discrimination of cell lines.
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Significant differences between cell lines are promising for diagnosis and sub classification of breast cancer.