Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function
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- 作者：Duojiao Wu1 ; 2 ; David E. Sanin1 ; 3 ; Bart Everts1 ; 4 ; Qiongyu Chen1 ; Jing Qiu1 ; 3 ; Michael D. Buck1 ; 3 ; Annette Patterson3 ; Amber M. Smith1 ; Chih-Hao Chang1 ; Zhiping Liu5 ; Maxim N. Artyomov1 ; Erika L. Pearce1 ; 3 ; Marina Cella1 ; Edward J. Pearce1 ; 3 ; 6 ; pearceed@ie-freiburg.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：44
- 期：6
- 页码：1325-1336
- 全文大小：2656 K
文摘
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Type 1 IFNs promote FAO and oxidative phosphorylation (OXPHOS)
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In CpG-stimulated pDCs, FAO is enhanced due to autocrine type 1 IFN signaling
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Increased FAO induced in pDCs by CpG-stimulation is essential for cellular activation
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Type 1 IFN-induced FAO is partly PPARα-dependent and has anti-viral properties