Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
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- 作者：Michael D. Buck1 ; 2 ; David O&rsquo ; Sullivan1 ; Ramon I. Klein Geltink1 ; Jonathan D. Curtis1 ; Chih-Hao Chang2 ; David E. Sanin1 ; Jing Qiu1 ; 2 ; Oliver Kretz3 ; 4 ; Daniel Braas5 ; Gerritje J.W. van der Windt6 ; Qiongyu Chen2 ; Stanley Ching-Cheng Huang2 ; Christina M. O&rsquo ; Neill2 ; Brian T. Edelson2 ; Edward J. Pearce1 ; 7 ; Hiromi Sesaki8 ; Tobias B. Huber3 ; 9 ; Angelika S. Rambold10 ; 11 ; Erika L. Pearce1 ; pearce@ie-freiburg.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：166
- 期：1
- 页码：63-76
- 全文大小：5005 K
文摘
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TM cells have fused mitochondria while TE cells have fissed mitochondria
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Mitochondrial fusion protein Opa1 is required for TM cells and not TE cells
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Enforcing fusion improves adoptive cellular immunotherapy against tumors
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Cristae remodeling via fusion/fission signals metabolic adaptations in T cells