DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
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- 作者：Laura Herrtwich1 ; 2 ; 29 ; Indrajit Nanda3 ; 29 ; Konstantinos Evangelou4 ; 29 ; Teodora Nikolova5 ; 29 ; Veronika Horn1 ; 29 ; Sagar6 ; Daniel Erny7 ; Jonathan Stefanowski8 ; Leif Rogell6 ; 9 ; 10 ; Claudius Klein11 ; Kourosh Gharun2 ; Marie Follo11 ; Maximilian Seidl12 ; Bernhard Kremer2 ; Nikolas Mü ; nke2 ; Julia Senges2 ; Manfred Fliegauf2 ; Tom Aschman1 ; Dietmar Pfeifer11 ; Sandrine Sarrazin13 ; Michael H. Sieweke13 ; 14 ; Dirk Wagner2 ; 15 ; Christine Dierks11 ; Thomas Haaf3 ; Thomas Ness16 ; Mario M. Zaiss17 ; Reinhard E. Voll1 ; Sachin D. Deshmukh18 ; Marco Prinz7 ; 19 ; Torsten Goldmann20 ; Christoph Hö ; lscher21 ; 22 ; 23 ; Anja E. Hauser8 ; Andres J. Lopez-Contreras24 ; Dominic Grü ; n6 ; Vassilis Gorgoulis4 ; 25 ; 26 ; 27 ; Andreas Diefenbach9 ; 10 ; diefenbach@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Philipp Henneke2 ; 28 ; Antigoni Triantafyllopoulou1 ; 2 ; 30 ; antigoni.triantafyllopoulou@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：macrophages ; granulomas ; DNA damage ; replication stress ; inflammation ; mycobacteria ; tuberculosis
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1264-1280.e18
- 全文大小：11958 K
文摘
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Polyploid macrophage fate is controlled by persistent inflammatory stimuli
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Polyploid granuloma macrophages form by modified cell divisions and mitotic defects
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Polyploid macrophages grow by overcoming p53-dependent barriers to their proliferation
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Myc and the DNA Damage Response promote polyploid macrophage differentiation