Eph receptor interclass cooperation is required for the regulation of cell proliferation
详细信息 查看全文
- 作者：Aleksandra Jureka ; 1 ; Maria Genandera ; 1 ; Parag Kundub ; c ; d ; Timothy Catchpolee ; Xiao Hea ; Klas Strå ; å ; ta ; Hanna Sabelströ ; ma ; Nan-Jie Xue ; Sven Petterssonb ; c ; d ; f ; Mark Henkemeyere ; Jonas Frisé ; na ; jonas.frisen@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Eph receptors ; Ephrins ; Intestinal stem cell niche ; Proliferation
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：10-22
- 全文大小：4588 K
文摘
- class="listitem" id="list_li0005">
- class="label">•
We demonstrate that ephrin-B1 and ephrin-B2 have largely non-overlapping functions in the intestinal stem cell niche.
- class="label">•
Ephrin-B1 regulates cell positioning and ephrin-B2 regulates cell proliferation in the intestinal stem cell niche.
- class="label">•
EphA4/B2 receptor cooperation in response to ephrin-B2 binding is obligatory to convey mitogenic signals in the intestine.
- class="label">•
EphA4 facilitates EphB2 phosphorylation in response to ephrin-B2 in SW480 adenocarcinoma cells.
- class="label">•
Ephrin-B1 and ephrin-B2 induce phosphorylation and degradation of the EphB2 receptor with different kinetics.